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liuR liuR liuA liuA liuD liuD liuB liuB atuA atuA liuC liuC liuE liuE aroP2 aroP2 PA0306 PA0306 atuH atuH PA4441 PA4441
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
liuRRegulator of liu genes; Class 1: Function experimentally demonstrated in P. aeruginosa. (134 aa)    
Predicted Functional Partners:
liuA
Putative isovaleryl-CoA dehydrogenase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.979
liuD
methylcrotonyl-CoA carboxylase, alpha-subunit (biotin-containing); Class 1: Function experimentally demonstrated in P. aeruginosa.
  
 
 0.950
liuB
methylcrotonyl-CoA carboxylase, beta-subunit; Class 1: Function experimentally demonstrated in P. aeruginosa.
 
  
 0.868
atuA
Expressed protein with apparent function in citronellol catabolism; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.772
liuC
Putative 3-methylglutaconyl-CoA hydratase; Class 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene; Belongs to the enoyl-CoA hydratase/isomerase family.
 
    0.732
liuE
3-hydroxy-3-methylglutaryl-CoA lyase; Involved in the L-leucine, isovalerate and acyclic monoterpene catabolism. Catalyzes the cleavage of 3-hydroxy-3- methylglutaryl-CoA (HMG-CoA) to yield acetyl-CoA and acetoacetate. It can also catalyze the cleavage of 3-hydroxy-3-isohexenylglutaryl-CoA (HIHG_CoA) to yield 7-methyl-3-oxooct-6-enoyl-CoA and acetate.
 
  
 0.717
aroP2
Aromatic amino acid transport protein AroP2; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
  
 0.711
PA0306
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
    
 
 0.704
atuH
Putative very-long chain acyl-CoA synthetase; Class 4: Homologs of previously reported genes of unknown function or no similarity to any previously reported sequences.
     
 0.702
PA4441
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.700
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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